Data · dataset · 2026
Investigating the role of the immune landscape in pancreatic ductal adenocarcinoma
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32639337.v1
This project investigates the interplay between host immune response and pancreatic ductal adenocarcinoma.
Description
Chapter 1 provides an overview of the incidence, mortality and treatment options for pancreatic cancer in addition to the current molecular understanding of pancreatic cancer. Chapter 2 is a systematic review and meta-analysis of tissue based immune based prognostic biomarkers in pancreatic cancer.
We identified high infiltration of CD4 and CD8 T cells associated with improved disease free survival in pancreatic cancer. High CD163 macrophage infiltration was associated with reduced overall survival, suggesting an important role of the immune response in pancreatic cancer outcome. Chapter 3 describes the creation of a Northern Ireland population based cohort of patients who underwent surgical resection of pancreatic cancer since 1996.
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Clinico-pathological and survival data was retrieved from the Northern Ireland Cancer Registry and multivariable survival analysis of 321 patients undertaken. Corresponding pathology slides were identified from the Belfast Trust histopathology laboratory and Chapter 4 describes how these were processed and uploaded to enable digital pathology analysis. A sample of the cohort was selected and the QuPath program used to undertake analysis of the association between tumour stroma percentage and survival in our cohort.
Chapter 5 describes our findings in the context of other work investigating the interplay between immunity and pancreatic cancer survival. It also discusses future research plans now this cohort has been identified and created, including the digital pathology analysis of the entire cohort and construction of tissue microarrays to investigate the association between tumour infiltration by immune cells and survival in our cohort of patients.
Links
Where it is published
- DOI doi.org/10.17034/32639337.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Cancer 75% · Disease 75% · Tumour immunology 76%
Provenance · 3 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32639337 | 11 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32639337 | 11 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32639337 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:320409 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (76%) |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |