10 datasets

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Over the last decade, cancer immunotherapy in the form of immune checkpoint inhibitor (ICI) therapy has provided an effective treatment strategy for several cancer types that are unresponsive to other forms of treatment. However, a large subset of solid tumours, designated as being “cold” in nature, cannot respond to ICI therapy due to limited T-cell infiltration within the tumour following the su

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Introduction<p>The emergence of SARS-CoV-2 Omicron subvariants has presented a significant challenge to global health, as these variants show resistance to most antibodies developed early in the pandemic. Therapeutic antibodies with potent efficacy to the Omicron variants are urgently demanded.</p>Methods<p>Utilizing the rapid antibody discovery platform, Berkeley Lights Beacon, we isolated two mo

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Introduction<p>The emergence of SARS-CoV-2 Omicron subvariants has presented a significant challenge to global health, as these variants show resistance to most antibodies developed early in the pandemic. Therapeutic antibodies with potent efficacy to the Omicron variants are urgently demanded.</p>Methods<p>Utilizing the rapid antibody discovery platform, Berkeley Lights Beacon, we isolated two mo

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Introduction<p>The emergence of SARS-CoV-2 Omicron subvariants has presented a significant challenge to global health, as these variants show resistance to most antibodies developed early in the pandemic. Therapeutic antibodies with potent efficacy to the Omicron variants are urgently demanded.</p>Methods<p>Utilizing the rapid antibody discovery platform, Berkeley Lights Beacon, we isolated two mo

ZivaHub + Deakin Research Online + DMU Figshare2026 · dataset

Introduction<p>The emergence of SARS-CoV-2 Omicron subvariants has presented a significant challenge to global health, as these variants show resistance to most antibodies developed early in the pandemic. Therapeutic antibodies with potent efficacy to the Omicron variants are urgently demanded.</p>Methods<p>Utilizing the rapid antibody discovery platform, Berkeley Lights Beacon, we isolated two mo

HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Single-cell RNA sequencing

<p>Single-cell RNA sequencing (scRNA-seq) methods are widely used in life sciences, including immunology. Typical scRNA-seq analysis pipelines quantify the abundance of particular transcripts without accounting for alternative splicing. However, a well-established pan-leukocyte surface marker, CD45, encoded by the PTPRC gene, presents alternatively spliced variants that define different immune cel

HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Single-cell RNA sequencing

<p>Single-cell RNA sequencing (scRNA-seq) methods are widely used in life sciences, including immunology. Typical scRNA-seq analysis pipelines quantify the abundance of particular transcripts without accounting for alternative splicing. However, a well-established pan-leukocyte surface marker, CD45, encoded by the PTPRC gene, presents alternatively spliced variants that define different immune cel

HKU DataHub + figshare + Loughborough Research Repository + UP Research Data Repository2026 · Single-cell RNA sequencing

<p>Single-cell RNA sequencing (scRNA-seq) methods are widely used in life sciences, including immunology. Typical scRNA-seq analysis pipelines quantify the abundance of particular transcripts without accounting for alternative splicing. However, a well-established pan-leukocyte surface marker, CD45, encoded by the PTPRC gene, presents alternatively spliced variants that define different immune cel

figshare + Loughborough Research Repository2026 · Astronomical catalogue · restricted

<p dir="ltr">This dataset accompanies a study characterising the immune microenvironment of IDH1-mutant intrahepatic cholangiocarcinoma (iCCA). By investigating the impact of the oncometabolite R-2HG on primary murine cells, novel immunotherapeutic strategies for IDH1-mutant iCCA were identified. The repository contains quantitative IDH1 expression data from engineered murine iCCA cell lines, alon

figshare2026 · Astronomical catalogue

<p dir="ltr">Venetoclax (VEN), in combination with hypomethylating agent, has become the standard of care for unfit and elderly patients with acute myeloid leukemia (AML) but relapse is common. Mechanisms of drug resistance are thought to be intrinsic to leukemic cells. We reported a hitherto undescribed mechanism of venetoclax resistance (VR) pertinent to CD8⁺ T cells activity and iden