N6-methyladenosine circRNA Epitranscriptomic Microarray analysis in peripheral blood of patients with β-thalassemia intermedia and major_10 samples

Circular RNAs (circRNAs) are functionally significant and hold tremendous potential as diagnostic biomarkers and therapeutic targets in numerous human diseases. Although the functional interplay between N6-methyladenosine (m6A) RNA modifications and circRNAs is becoming increasingly well understood, their specific cross-talk in β-thalassemia remains poorly characterized.

Here, we aim to identify the differentially expressed m6A circRNAs in β-thalassemia and elucidate the function of m6A modification and the mechanism by which circRNAs regulate erythropoiesis.