Omics · study · 2026
Hepatic transcriptome profiling of wild-type mice treated with GalNAc-siRnf10
Listed in NCBI GEO
This study aimed to investigate the hepatic transcriptomic effects of GalNAc-conjugated siRNA-mediated Rnf10 knockdown in vivo.
Description
Wild-type mice were maintained on a normal chow diet and treated with GalNAc-siNC or GalNAc-siRnf10 at the indicated time points. Liver tissues were collected at the end of the experiment and subjected to bulk RNA sequencing.
Differential gene expression analysis was performed to identify genes and pathways altered by GalNAc-siRnf10 treatment. Seed match enrichment analysis was further used to evaluate potential off-target effects associated with the siRnf10 guide strand.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337995 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337995 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1492057 ncbi.nlm.nih.gov/bioproject/PRJNA1492057 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337995 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |