Table · study · 2026
Spatial transcriptomic profiling of bone marrow from KrasG12D/+ and wild-type mice
Listed in NCBI GEO
Spatial transcriptomic profiling was performed on whole bone marrow sections from KrasG12D/+ and wild-type mice.
Description
Frozen 10-µm bone marrow sections were processed by Biomarker Technologies Corporation (Beijing, China) following standard spatial transcriptomics procedures, including tissue fixation, H&E staining, permeabilization, reverse transcription, and spatial cDNA library construction. Libraries were sequenced on an Illumina NovaSeq 6000 (PE150).
Spot-level gene expression matrices were generated using BSTMatrix, aligned with corresponding bright-field images, and tissue-covered spots were identified for downstream analysis. Spatial mapping revealed spatially resolved patterns of gene expression and cellular organization within bone marrow. These data provide comprehensive spatial transcriptomic information enabling investigation of bone marrow architecture and microenvironmental interactions in Kras-driven JMML.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313878 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313878 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1381719 ncbi.nlm.nih.gov/bioproject/PRJNA1381719 ↗
project · from NCBI GEO
Topics
- Stated by source
- Mus musculus · Other
- From keywords
- Life Sciences
- Inferred from text
- Bioinformatics and computational biology 69% · Image 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313878 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3102 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:image | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |