Supplementary file 1_Plasma amino acid metabolic alterations and their associations with ocular parameters in early primary angle-closure glaucoma.docx

In addition, intraocular pressure (IOP) was significantly higher (20.9 ± 2.5 vs. 14.2 ± 2.4 mmHg, P < 0.001), axial length (AL) was shorter (22.8 ± 0.1 vs. 23.2 ± 0.2 mm, P < 0.001), and lens thickness (LT) was greater (4.8 ± 0.2 vs. 4.3 ± 0.2 mm, P < 0.001) in early PACG patients than in healthy controls. Reduced retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, and superficial vascular complex vessel density in the peripapillary and macular regions were observed in early PACG patients compared with healthy controls (all P < 0.05).

We further identified five amino acids that showed a positive correlation with IOP and LT, and a negative correlation with AL, as well as with the thickness of the RNFL and GCC in the central 3–6 mm annular region (all P < 0.05).</p>Conclusion<p>The plasma of early PACG patients showed distinctive metabolic profiles, which provided new insights into the pathogenesis of the early phase of PACG patients.</p>