Omics · study · 2026
ZEB1-IL-6 axis promotes cancer stem cell properties in breast cancer
Listed in NCBI GEO
ZEB1 plays a pivotal role in the pathogenesis of breast cancer and therapeutic resistance by promoting cancer stem cells (CSCs).
Description
Cytokines and chemokines secreted by tumor cells are also critically involved in tumor progression. However, the relationship between ZEB1 and these molecules remains poorly understood.
This study therefore investigated the pro-carcinogenic role of ZEB1 overexpression in affecting the autocrine pathway in tumor cells. Here, we verified that ZEB1 acts as a transcription factor in MDA-MB-231 cells, promoting IL-6 expression. Elevated IL-6 significantly enhanced the stemness of MDA-MB-231 cells in vitro, as well as promoting tumor formation in a mouse transplantation tumor model.
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Notably, administration of IL-6 neutralizing antibodies was found to significantly inhibit tumor growth. Furthermore, knockdown of IL-6 in ZEB1-overexpressing MDA-MB-231 cells attenuated stemness, confirming the functional role of the ZEB1-IL-6 axis in promoting tumor stemness. Collectively, these results establish a theoretical foundation for a dual therapeutic approach that targets both ZEB1 and cytokines.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE305nnn/GSE305584 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE305584 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1306587 ncbi.nlm.nih.gov/bioproject/PRJNA1306587 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE305584 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |