Omics · study · 2026
Pharmacological Clearance of Senescent Cells Alleviates Bone Marrow Aging
Listed in NCBI GEO
Aging of the hematopoietic system impairs HSC function and alters bone marrow niche behavior, increasing susceptibility to anemia, infections, and hematologic malignancies.
Description
Here, we employed the novel BCL-xL/BCL-2-targeted senolytic 753b to pharmacologically clear senescent cells in aged animals, evaluating its safety, efficacy, and restorative benefits to hematopoiesis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE316nnn/GSE316278 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316278 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1402148 ncbi.nlm.nih.gov/bioproject/PRJNA1402148 ↗
project · from NCBI GEO
- PubMed 42523366 pubmed.ncbi.nlm.nih.gov/42523366 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE316278 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |