Study on the Molecular Mechanism of BMP8B in Regulating Trophoblast Cell Function: A Transcriptomic Analysis Based on RNA-seq

As a member of the bone morphogenetic protein family, BMP8B has been demonstrated to participate in regulating the migration, invasion, and differentiation of trophoblast cells. To deeply elucidate the specific molecular pathways by which BMP8B regulates trophoblast cell function, this study employed RNA sequencing technology to systematically analyze the transcriptomic differences between HTR8/SVneo cells treated with BMP8B for 24 hours and untreated control cells.

Through screening of differentially expressed genes, functional enrichment analysis, and mining of key signaling pathways, we aim to reveal the downstream regulatory network of BMP8B in trophoblast cells, providing a molecular basis for understanding the pathogenesis of placenta-related diseases.