Table · dataset · 2026
Supplementary Datasets and Data-Package for <b><i>CRISPR-enhanced assessment of variants of unknown significance nominates oncology therapeutic targets and drug repositioning opportunities</i></b> Savino et Al. 2026
Listed in HKU DataHub and figshare and Loughborough Research Repository and UP Research Data Repository — shown once because both records carry DOI 10.6084/m9.figshare.33435853.v6
Description
<p dir="ltr">This repository contains supplementary datasets and the data package required to reproduce the analysis, results, and figures presented in Savino et al. (2026).<br><br>The study leverages CRISPR-based functional genomics to systematically evaluate Variants of Unknown Significance (VUS) in oncology, identifying actionable therapeutic targets and highlighting novel opportunities for drug repositioning.<br><br>The complete computational workflow is available at github.com/francescojm/CRISPR-VUS.</p><p dir="ltr">The repository contains a Jupyter notebook, accompanying R scripts, configuration files, software-environment information and instructions for reproducing the analyses and figures.
The notebook can also be accessed through Google Colab (at colab.research.google.com/drive/1PkduxjbHQH4zZxk3g69LWQUGL_jsL-aq?usp=sharing).</p><p><br></p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.33435853.v6 ↗
DOI / persistent id · from datahub hku hk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from datahub hku hk
Topics
- From keywords
- Astronomy & Astrophysics · Bioinformatic methods development · Bioinformatic methods development · Bioinformatic methods development · Bioinformatic methods development · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Engineering · Genomics and transcriptomics · Genomics and transcriptomics · Genomics and transcriptomics · Genomics and transcriptomics · Humanities · Humanities · Humanities · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Mathematics & Statistics · Mathematics & Statistics · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science · Social Science · Statistical and quantitative genetics · Statistical and quantitative genetics · Statistical and quantitative genetics · Statistical and quantitative genetics
Provenance · 4 source records, 50 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| HKU DataHub | oai:figshare.com:article/33435853 | 5 d ago | JSON v1 |
| figshare | oai:figshare.com:article/33435853 | 4 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/33435853 | 4 d ago | JSON v1 |
| UP Research Data Repository | oai:figshare.com:article/33435853 | 4 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].anzsrc:field:310201 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Bioinformatic methods development'] |
| concepts[field].anzsrc:field:310201 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Bioinformatic methods development'] |
| concepts[field].anzsrc:field:310201 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Bioinformatic methods development'] |
| concepts[field].anzsrc:field:310201 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Bioinformatic methods development'] |
| concepts[field].anzsrc:field:310204 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Genomics and transcriptomics'] |
| concepts[field].anzsrc:field:310204 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Genomics and transcriptomics'] |
| concepts[field].anzsrc:field:310204 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Genomics and transcriptomics'] |
| concepts[field].anzsrc:field:310204 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Genomics and transcriptomics'] |
| concepts[field].anzsrc:field:310207 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Statistical and quantitative genetics'] |
| concepts[field].anzsrc:field:310207 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Statistical and quantitative genetics'] |
| concepts[field].anzsrc:field:310207 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Statistical and quantitative genetics'] |
| concepts[field].anzsrc:field:310207 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Statistical and quantitative genetics'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| description | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/description |
| license | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/rights |
| publication_date | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| title | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/title |