Omics · study · 2026
Inducible endothelial Plvap knockout RPE-choroid tissue sinlge cell transcriptomic analysis
Listed in NCBI GEO
This single-cell RNA-sequencing dataset was generated to investigate cellular and transcriptional changes following endothelial PLVAP loss in the adult mouse retina–choroid.
Description
Control and inducible endothelial-specific PLVAP knockout (PLVAPiECKO) mice were analyzed 10 days after PLVAP deletion. Single-cell transcriptomic profiling was used to characterize major retinal and choroidal cell populations and to examine PLVAP-loss-associated changes in choriocapillaris endothelial cells, retinal pigment epithelial cells, and photoreceptors.
The dataset provides a cellular framework for understanding how disruption of PLVAP-dependent endothelial fenestration affects vascular–tissue exchange and metabolic homeostasis in the outer retina.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345745 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345745 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1521799 ncbi.nlm.nih.gov/bioproject/PRJNA1521799 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE345745 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |