Excel · study · 2026
Immune Activation and Candidate Prognostic Marker Discovery in Bladder Cancer: A Preclinical Mouse Study of Recombinant M. smegmatis
Listed in NCBI GEO
This study investigated transcriptomic alterations associated with rSmeg-hMIF-hIL-7 treatment in a syngeneic MBT-2 bladder cancer mouse model.
Description
Female C3H/He mice bearing subcutaneous MBT-2 tumors received either PBS or rSmeg-hMIF-hIL-7 by intraperitoneal injection every other day. Tumor tissues were subjected to bulk RNA sequencing to characterize treatment-associated gene-expression changes and biological pathways related to immune activation, apoptosis, angiogenesis, cell adhesion, and tumor progression.
A total of seven tumor samples were sequenced. The deposited dataset contains four PBS control samples and three rSmeg-hMIF-hIL-7-treated samples.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343866 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343866 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1513066 ncbi.nlm.nih.gov/bioproject/PRJNA1513066 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE343866 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |