Enhancing the radio sensitivity of prostate cancer using RALA Gold nano-complexes

RALA-AuNP have undergone extensive characterisation following synthesis, proving optimal for in vitro and in vivo application. Significant improvements in cell uptake and localisation of AuNP have been presented. At the time of writing this thesis includes the first work to definitively confirm Au uptake into the nucleus.

Most importantly RALA-AuNP induced significant radiosensitisation at both research and clinically relevant energies at Au concentrations several orders of magnitude lower than previous literature. As such, the findings within this thesis extend our knowledge of radiosensitisers, in particular highlighting the clinical radiosensitising potential of gold nanoparticles.