Omics · study · 2026
Bulk RNAseq of sorted fibroblasts from a mouse model of stretch-mediated skin expansion
Listed in NCBI GEO
Using an in vivo mouse model of stretch-mediated skin expansion, we have performed bulk RNAseq on control (CTRL) skin fibroblasts and expanded (EXP) skin fibroblasts at 3 time points: day 1, day 2 and day 4.
Description
Stretch-mediated expansion is used in reconstructive and cosmetic surgeries to produce extra skin, however the mechanisms behind it are not well understood. Here we investigate the transcriptional changes occurring in fibroblasts upon expansion.
We find downregulation of many extracellular matrix genes, including collagens, and upregulation of genes related to mitosis and sterol biosynthesis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE284nnn/GSE284808 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284808 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1200691 ncbi.nlm.nih.gov/bioproject/PRJNA1200691 ↗
project · from NCBI GEO
- PubMed 42285958 pubmed.ncbi.nlm.nih.gov/42285958 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE284808 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |