Omics · study · 2026
Eucommia ulmoides Leaf-Derived Exosomes Ameliorate Replicative Senescence in 3D Skin Models via HES1-Mediated Stemness Reprogramming and Multi-Pathway Network Regulation
Listed in NCBI GEO
ELEs orchestrate a multi-dimensional reversal of replicative senescence in 3D skin models through telomere protection, replication stress alleviation, inflammation suppression, and ECM homeostasis remodeling.
Description
These effects are mechanistically coordinated by HES1-mediated stemness reprogramming and the concerted modulation of MAPK signaling (particularly the ERK cascade), PI3K/AKT, and cAMP signaling networks. This study provides robust experimental evidence supporting the development of Eucommia ulmoides leaf exosomes as a natural, multi-targeted nanoplatform for skin anti-aging applications
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE348nnn/GSE348048 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE348048 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1532753 ncbi.nlm.nih.gov/bioproject/PRJNA1532753 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Non-coding RNA profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE348048 | 8 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |