Omics · study · 2026
Immunogen-Sponge Hydrogel Reverses TIM-3–Mediated Dendritic-Cell Exhaustion in Alveolar Echinococcosis
Listed in NCBI GEO
Alveolar echinococcosis (AE) induces profound dendritic-cell dysfunction characterized by elevated TIM-3 expression and impaired antigen presentation.
Description
To overcome parasite-induced immunosuppression, we developed a SHIFT-engineered Immunogen-Sponge hydrogel vaccine incorporating protoscolex-derived antigens (PSAs). Bone marrow-derived dendritic cells (BMDCs) were treated with saline, PSA, F127@PSA, or SHIFT-F127@PSA and subjected to transcriptome sequencing.
Comparative transcriptomic analyses were performed to investigate dendritic-cell activation, antigen presentation, immune signaling pathways, and TIM-3-associated regulatory mechanisms.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334769 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334769 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1476314 ncbi.nlm.nih.gov/bioproject/PRJNA1476314 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE334769 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |