Omics · study · 2026
P2X7-mediated mitochondrial calcium overload induces CD8+ T cell senescence
Listed in NCBI GEO
Neutral lipid levels (Bodipy 493/503) were increased in aged CD8⁺ T cells.
Description
We thus selectively removed the lipid sensing transcription factor Rxra and Rxrb in T-lineage cells (Cd4-Cre⁺/⁻ Rxra^f/f Rxrb^f/f; hereafter TDKO). Preliminary phenotyping confirmed that TDKO mice harbour a higher frequency of senescent (fSA-βGal⁺) CD8⁺ T cells relative to wild-type (WT) controls, prompting a comparative survey.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303869 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303869 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1298157 ncbi.nlm.nih.gov/bioproject/PRJNA1298157 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE303869 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |