Omics · study · 2026
The Histone Demethylase KDM6B Restrains Hypermetabolic LYVE1+ Perivascular Macrophages and Preserves Adipogenic Balance [RNA-seq wat]
Listed in NCBI GEO
We employed a bulk RNA sequencing approach to study transcriptional remodeling of white adipose tissue in wild-type and macrophage-specific KDM6B knockout mice fed a high-fat diet for 5 weeks.
Description
Subcutaneous white adipose tissue and epididymal white adipose tissue were collected and analyzed, with three biological replicates per group. This study was designed to identify depot-specific and genotype-dependent gene expression changes associated with diet-induced obesity.
These data provide insights into macrophage-dependent regulation of adipose tissue inflammation, metabolic dysfunction, extracellular matrix remodeling, and tissue adaptation during chronic high-fat diet feeding.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338875 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338875 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1496278 ncbi.nlm.nih.gov/bioproject/PRJNA1496278 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE338875 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |