Text · study · 2026
Epithelial BMP signaling regulates gastric tissue responses upon H. pylori infection
Listed in NCBI GEO
In the gastric mucosa, BMP signaling is known to regulate the differentiation of progenitor epithelial cells into differentiated pit secretory mucous cells thanks to BMP ligands production in stromal cells located at the gland pit and to BMP antagonists secretion at the gland base.
Description
Upon Helicobacter pylori infection there is an alteration of ligands and antagonists production which ultimately results in BMP signaling downregulation in the gastric epithelium.
We investigate the correlation of BMP signaling downregulation with the development of hyperplasia and inflammation exploiting a conditional mouse model that allows the inhibition of BMP signaling in gastric glands via Axin2CreErt2:Bmpr1a fl/fl.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE283nnn/GSE283811 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE283811 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1195607 ncbi.nlm.nih.gov/bioproject/PRJNA1195607 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE283811 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |