Omics · study · 2026
Investigation of gene expression in human brain samples
Listed in NCBI GEO
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by a gradual decline in neuronal activity, which affects memory and thinking.
Description
As it progresses, it can interfere with daily life, and it can eventually lead to death. AD accounts for approximately 60-70% of dementia cases and is particularly prevalent in the elderly.
However, the gene regulatory mechanism for AD development in human brain tissues is still unclear. To deepen our understanding of the molecular mechanims involved in this cognitive decline, we conducted RNA-sequencing (RNA-seq) on six brain tissues from both control (Ct) without dementia and AD patients to analyze differentially expressed genes (DEGs) between Ct and AD brains.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328648 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328648 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1456059 ncbi.nlm.nih.gov/bioproject/PRJNA1456059 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328648 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |