Excel · study · 2026
Whole genome CRISPR drop-out screen in THP-1 cells exposed to mebendazole
Listed in NCBI GEO
We previously reported that mebendazole is an effective anti-AML therapeutic and acts via induction of MYB degradation.
Description
The present experiemnt was performed in order to uncover pathways of potential resistance in AML cells to mebendazole exposure. A whole genome CRISPR drop-out screen was performed on THP-1 AML cells exposed to 1 micromolar mebendazole or DMSO in order to identify genes that decreased AML sensitivity to this drug.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE293nnn/GSE293063 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE293063 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1242722 ncbi.nlm.nih.gov/bioproject/PRJNA1242722 ↗
project · from NCBI GEO
- PubMed 42120360 pubmed.ncbi.nlm.nih.gov/42120360 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE293063 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |