Omics · study · 2026
Single-nucleus transcriptomic atlas of the mouse medial thalamus
Listed in NCBI GEO
The mediodorsal thalamus and adjacent midline nuclei are critical for higher-order cognition and neuropsychiatric disease, yet their cellular organization remains incompletely defined.
Description
The objective of this study was to characterize the cellular composition and transcriptional organization of the mouse medial thalamus. Single-nucleus RNA sequencing was used to identify neuronal cell types, assign transcriptional clusters to anatomical nuclei, and define gene expression patterns underlying thalamic organization.
A further goal was to compare these features across species to identify conserved transcriptional patterns and differences in cell type composition, including neuronal populations expanded in humans relative to mice. This dataset provides a transcriptomic atlas of the medial thalamus and a resource for investigating cell type diversity, functional organization, and cross-species specialization.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328074 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328074 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1453811 ncbi.nlm.nih.gov/bioproject/PRJNA1453811 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75% · Zoology 68%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328074 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3109 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (68%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |