Omics · study · 2026
Cytokine gene combination on iPS cell-derived T cells synergistically improves migration, proliferation, and memory formation in solid tumors
Listed in NCBI GEO
T cells show anti-tumor efficacy against solid tumor by infiltration, proliferation, and antigen-specific cytotoxicity.
Description
In this study, we investigated various combinations of cytokine gene modifications in chimeric antigen receptor-transfected induced pluripotent stem cell-derived T cells (iCAR-T cells). Effective combinations enhanced the anti-tumor efficacy of iCAR-T cells against solid tumors.
The combination of interleukin 15 (IL-15) and IL-21 gene modification maintained the infiltration and persistency of iCAR-T cells in tumors and significantly prolonged the survival of a subcutaneous tumor-bearing mouse model. This gene combination was found to enhance the expression of genes related to proliferation, chemotaxis and memory formation. Thus, the IL-15 and IL-21 combination may accelerate the therapeutic efficacy of iCAR-T cells for solid tumor immunotherapies as a substitute of peripheral blood CD8 T cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE252nnn/GSE252998 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE252998 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1055728 ncbi.nlm.nih.gov/bioproject/PRJNA1055728 ↗
project · from NCBI GEO
- PubMed 42127898 pubmed.ncbi.nlm.nih.gov/42127898 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE252998 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |