Omics · study · 2026
miR-30d suppresses innate immune signaling in cancer cells by attenuating the cGAS/STING/IFN-I cascade via a LATS2/YAP axis
Listed in NCBI GEO
In cancer cells, miR-30d expression is cooperatively induced by HIF1α and missense mutp53 oncoproteins in response to hypoxia and ECM stiffness.
Description
In turn, miR-30d remodels the secretory pathway, particularly by promoting Golgi tubulo-vesiculation, leading to the release of a malignant secretome that drives ECM stiffening, CAF activation, and angiogenesis both at primary tumor sites and premetastatic niches.To investigate the impact of miR-30d inhibition on gene expression in early BC, we performed RNA-seq in MCF10 DCIS (MCF10DCIS.com cell line) cells treated with LNA-30d or control.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE302nnn/GSE302728 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302728 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1291807 ncbi.nlm.nih.gov/bioproject/PRJNA1291807 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE302728 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |