Excel · study · 2026
RalA-driven CCN3 secretion amplifies inflammatory catabolism to promote temporomandibular joint osteoarthritis
Listed in NCBI GEO
This project investigates the role of RalA in temporomandibular joint osteoarthritis using a mouse MIA-induced TMJOA model and primary mouse temporomandibular joint condylar chondrocytes.
Description
Transcriptomic profiling of siNC- and siRalA-transfected chondrocytes was performed to identify RalA-regulated inflammatory and extracellular matrix remodeling pathways. The study identifies CCN3 as a RalA-regulated secreted mediator that amplifies inflammatory cytokine production and cartilage catabolism.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338438 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338438 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1494478 ncbi.nlm.nih.gov/bioproject/PRJNA1494478 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE338438 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |