Omics · study · 2026
SEX-DEPENDENT TYPE I INTERFERON SIGNALING EXACERBATES ALZHEIMER'S PATHOLOGY
Listed in NCBI GEO
Alzheimer’s disease (AD) disproportionately affects women, but the biological basis for this sex difference remains unclear.
Description
Using transcriptomic profiling of postmortem human AD brain tissue, we identified a sex-specific enrichment of interferon-alpha (IFN-α) signaling pathways in females. This immune signature was recapitulated in APP/PS1 transgenic mouse models, where female mice exhibited greater amyloid pathology, neuroinflammation, and neurodegeneration compared to males.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304521 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304521 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1301423 ncbi.nlm.nih.gov/bioproject/PRJNA1301423 ↗
project · from NCBI GEO
- PubMed 42083037 pubmed.ncbi.nlm.nih.gov/42083037 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE304521 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |