Omics · study · 2026
Blocking dMIC60 Oxidation Drives Mitochondrial-Nuclear Crosstalk and Promotes Resilience
Listed in NCBI GEO
Mitochondria communicate their functional and redox states to the nucleus to coordinate cellular adaptation, but how proteins that regulate mitochondrial ultrastructure participate in this signaling remains incompletely understood.
Description
MIC60 is a core component of the mitochondrial contact site and cristae organizing system and is susceptible to redox-dependent regulation. Here, we investigate the molecular and physiological consequences of blocking oxidation of Drosophila MIC60 (dMIC60).
Transcriptomic analysis reveals coordinated increases in mitochondrial, metabolic, and nuclear gene programs in female flies expressing oxidation-resistant dMIC60-CS compared with those expressing wild-type dMIC60-WT. Notably, timeout, a TIMELESS-family gene implicated in circadian regulation and genome maintenance, is among the most highly upregulated genes. dMIC60-CS females exhibit increased sleep, extended lifespan, and improved locomotor performance, consistent with the transcriptomic signatures.
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Mitochondrial ultrastructure and membrane potential are preserved, indicating that the transcriptional response is not associated with overt mitochondrial dysfunction. In MIC60-null HeLa cells, dMIC60-CS expression similarly increases TIMELESS abundance and resistance to oxidative stress. These findings identify the dMIC60 oxidation state as a potential regulator of a conserved mitochondria-to-nucleus signaling pathway that coordinates metabolism, stress resistance, and organismal physiology.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346353 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346353 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1525009 ncbi.nlm.nih.gov/bioproject/PRJNA1525009 ↗
project · from NCBI GEO
Topics
- Stated by source
- Drosophila melanogaster · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 70%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE346353 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:7227 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |