Table · dataset · 2026
Data Sheet 1_Two cases of large cell neuroendocrine carcinoma of the gallbladder: case reports and systemic literature review.docx
Listed in HKU DataHub and figshare and Loughborough Research Repository — shown once because both records carry DOI 10.3389/fmed.2026.1885339.s001
<p>As gallbladder large cell neuroendocrine carcinoma (GB-LCNEC) is extremely rare and highly aggressive, with limited reports in both domestic and international literature, we herein report two cases of GB-LCNEC accompanied by contiguous high-grade intraepithelial neoplasia of the overlying mucosa.
Description
One of the patients had pancreaticobiliary maljunction. Microscopically, the tumor cells were large and arranged in organoid, nested, palisading or trabecular patterns.
They exhibited abundant cytoplasm, vesicular nuclei with coarse granular chromatin, prominent nucleoli, and mitotic figures exceeding 20 per 2 mm<sup>2</sup>. Immunohistochemically, both tumors showed diffuse positivity for the neuroendocrine markers chromogranin A (CgA) and synaptophysin (Syn), and both exhibited a Ki-67 proliferative index exceeding 20%. They demonstrated wild-type and aberrant (mutant) p53 expression patterns, respectively.
Read the rest (2 more)
Although the 2 cases reported in this study were confirmed to have space-occupying lesions in the gallbladder via CT/MRI, preoperative diagnosis was not achieved due to insufficient understanding of the disease. Through a systematic literature review, this study delineates the clinicopathologic and molecular features, diagnostic criteria, differential diagnoses, treatment, and prognosis of GB-LCNEC, as well as its potential pathogenesis/origin that may involve a multistep carcinogenic process of chronic inflammation–metaplasia–dysplasia–carcinogenesis.
It aims to enhance clinical understanding of this rare disease and lay the foundation for future related research.</p>
Links
Where it is published
- DOI doi.org/10.3389/fmed.2026.1885339.s001 ↗
DOI / persistent id · from datahub hku hk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from datahub hku hk
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Foetal development and medicine · Foetal development and medicine · Foetal development and medicine · Humanities · Humanities · Life Sciences · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science
- Inferred from text
- Cancer 65% · Computed tomography 50% · Disease 75% · Magnetic resonance imaging 65%
Provenance · 3 source records, 38 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| HKU DataHub | oai:figshare.com:article/34008366 | 11 d ago | JSON v1 |
| figshare | oai:figshare.com:article/34008366 | 10 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/34008366 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · datahub hku hk | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[disease].local:disease:disease | enrichment · datahub hku hk | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:321501 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Foetal Development and Medicine'] |
| concepts[field].anzsrc:field:321501 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Foetal Development and Medicine'] |
| concepts[field].anzsrc:field:321501 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Foetal Development and Medicine'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[modality].local:modality:ct | enrichment · datahub hku hk | keyword-concept-rules@1.0.0 | title+description (50%) |
| concepts[modality].local:modality:mri | enrichment · datahub hku hk | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/description |
| license | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/rights |
| publication_date | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| title | source · datahub hku hk | connector:datahub_hku_hk@1.0.0 | /metadata/dc/title |