Omics · study · 2026
Maternal pre-conceptional underweight induces fetal growth restriction via placental DNA methylation alterations
Listed in NCBI GEO
An increasing number of individuals are striving for ideal body figures, and reproductive-aged females with a body mass index (BMI) less than 18.5kg/m2 account for a significant proportion.
Description
However, the effects of maternal pre-conceptional underweight on fetal growth remain poorly explored. Epigenetic modifications are crucial in regulating the expression of development-related genes in the placenta.
This study aims to investigate the impact of maternal pre-conceptional underweight on fetal growth and the associated epigenetic mechanisms in the placenta.In conclusion, our findings illustrated that DNA methylation abnormality of the energy-related genes in the placenta represented a key mechanism between maternal pre-gestational exposure to underweight and fetal development, highlighting the importance of pre-conceptional interventions in reducing the effects of maternal unhealthy exposure on offspring health.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE290nnn/GSE290409 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE290409 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1226764 ncbi.nlm.nih.gov/bioproject/PRJNA1226764 ↗
project · from NCBI GEO
- PubMed 41826896 pubmed.ncbi.nlm.nih.gov/41826896 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Methylation profiling by high throughput sequencing
- From keywords
- Life Sciences
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE290409 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:methylation-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |