Omics · study · 2026
Modeling therapy sequencing in IDH-mutant glioma reveals that the mutant IDH inhibitor vorasidenib improves chemoradiation response
Listed in NCBI GEO
The mutant IDH1/2 inhibitor (mIDHi) vorasidenib was recently incorporated into clinical treatment guidelines for IDH-mutant gliomas, although its impact on chemoradiation is unclear.
Description
Specifically, it is unknown whether upfront mIDHi exposure alters subsequent chemoradiation efficacy. Addressing this critical question has been challenging due to limited clinical data and a paucity of mIDHi-responsive preclinical glioma models.
We aggregated 29 patients across three institutions who were among the earliest to receive mIDHi prior to radiation+/-chemotherapy. We report outcomes of these patients compared to a similarly treated mIDHi-naïve cohort. To empirically address how mIDHi affects chemoradiotherapy efficacy, we used a mIDHi-responsive genetic mouse model of IDH-mutant astrocytoma.
Read the rest (1 more)
Mice that received vorasidenib before chemoradiation (vorasidenib-->chemoradiation) had improved survival compared to control mice (vehicle-->chemoradiation). In sum, we find no evidence from emerging real-world clinical data that upfront mIDHi therapy diminishes efficacy of subsequent chemoradiation. Moreover, preclinical modeling demonstrates that prior vorasidenib treatment enhances, rather than impairs, chemoradiation sensitivity of IDH-mutant glioma.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328196 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328196 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1454117 ncbi.nlm.nih.gov/bioproject/PRJNA1454117 ↗
project · from NCBI GEO
- PubMed 42555757 pubmed.ncbi.nlm.nih.gov/42555757 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328196 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |