Table 1_Risk factors for hypoglycemia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.docx

Observational studies reporting risk factors for hypoglycemia were included. Study quality was assessed using the Newcastle-Ottawa Scale or AHRQ checklist.

Odds ratios (ORs) were pooled using random- or fixed-effects models.</p>Results<p>Ten studies (n = 4,945; hypoglycemia 1,647; non- hypoglycemia 3,298) were included. Longer diabetes duration (OR 2.67, 95% CI 1.81–3.95), insulin therapy (OR 2.46, 95% CI 1.93–3.15), comorbidities (OR 1.79, 95% CI 1.17–2.75), and polypharmacy (OR 4.73, 95% CI 3.07–7.30) were associated with higher odds of hypoglycemia. Higher HbA1c (OR 0.59, 95% CI 0.44–0.81) and self- monitoring of blood glucose (OR 0.52, 95% CI 0.49–0.56) were associated with lower odds.