Omics · study · 2026
Image Tracing of Inflammatory Intestinal Organoids via Computational Clearing
Listed in NCBI GEO
Gene expression of dextran sulfate sodium (DSS)-treated mouse intestinal organoids (mIOs) was examined by RNA-seq to characterize the inflammatory response.
Description
Gene set enrichment analysis (GSEA) revealed the upregulation of inflammatory pathways, including TNF-α signaling via NF-κB and IL-6/JAK/STAT3 signaling, alongside the downregulation of stem cell maintenance and proliferation pathways, including WNT/β-catenin signaling and PI3K/AKT/mTOR signaling.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328646 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328646 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1456065 ncbi.nlm.nih.gov/bioproject/PRJNA1456065 ↗
project · from NCBI GEO
- PubMed 42188524 pubmed.ncbi.nlm.nih.gov/42188524 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Image 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328646 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:image | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |