Omics · study · 2026
ChIP-seq of H3K27ac and H3K27me3 in the hippocampus of C57BL/6 mice after high methionine feeding for more than 8 weeks.
Listed in NCBI GEO
To explore whether high homocysteine status affects the enrichment of histone H3K27ac and H3K27me3 and thus affects the cognitive behavioral abilities of mice, we fed C57BL/6 mice with a high-methionine diet and a standard diet, then isolated the hippocampus for ChIP-seq studies of H3K27ac and H3K27me3.
Description
The sequencing data provided a new theoretical basis for the effects of high homocysteine on histone modification.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE280nnn/GSE280827 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE280827 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1180633 ncbi.nlm.nih.gov/bioproject/PRJNA1180633 ↗
project · from NCBI GEO
- PubMed 40903958 pubmed.ncbi.nlm.nih.gov/40903958 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE280827 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |