Omics · study · 2026
Electromagnetic exposure changes human Schwann cells motility and transcriptomic profile of hearing-loss related genes
Listed in NCBI GEO
Schwann cells (SCs) are glial cells of the peripheral nervous system with functional plasticity in physio-pathological conditions, as injury, and oncotransformation.
Description
Interestingly, human SCs seem to develop, mature, and respond differently to other species to environmental challenges. Recently, concerns raised about the expansion of environmental electromagnetic fields (EMF) and the increasing incidence of vestibular schwannoma (VS).
We previously demonstrated that SCs respond to EMF by acquiring a state prone to oncotransformation. However, the biodependence of such transformation on the species (rodents versus human) deserves clarification. Here, we obtained and characterized human SCs, showing that EMF affects proliferation, migration, and transcriptomic profile.
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The expression of motility proteins increased, while those of cell-to-cell adhesion proteins decreased. The functional clustering of genes differentially expressed matched with those involved in hearing loss. In summary, we provide insights into the effects of chronic EMF on human SCs, highlighting its potential role in VS onset.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE322nnn/GSE322769 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE322769 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1431452 ncbi.nlm.nih.gov/bioproject/PRJNA1431452 ↗
project · from NCBI GEO
- PubMed 41858877 pubmed.ncbi.nlm.nih.gov/41858877 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE322769 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |