Table 1_Specialized pro-resolving mediators and cancer: news and promises from the other side of the moon.docx

This persistent inflammatory context has supported the prescient view of tumors as “wounds that do not heal.” While the pro-tumorigenic functions of inflammatory lipid mediators, such as prostaglandin E₂, are well established, the contribution of defective resolution programs to cancer progression remains less clear. This review examines the lipid mediator networks linking the initiation and resolution of inflammation in solid tumors, focusing on the mechanistic roles of SPMs in the tumor microenvironment and the emerging translational opportunities to restore pro-resolving signaling.

This supports a re-evaluation of cancer-associated inflammation from the perspective of failed resolution, opening avenues for therapeutic strategies targeting resolution to mitigate therapy resistance. We develop this idea by bringing together direct and indirect scientific evidence, explicitly distinguished throughout the text and summarized in a dedicated evidence table, and by focusing on a prospective pharmacological scenario.

This is a narrative review; its scope, literature search strategy, and limitations are described in Sections 1.1, 1.2, and 8.</p>