Omics · study · 2026
High-resolution transcriptomic profiles of kidney distal convoluted tubules in male and female mice
Listed in NCBI GEO
Sexual dimorphic responses to physiological factors in the kidney have been emerging as important considerations for understanding kidney physiology and pathophysiology.
Description
Here, we report high-resolution transcriptome profiles of distal convoluted tubules isolated from the kidneys of male and female mice. Transcriptomic analysis based on RNA-Seq cooupled with tubule microdissection was carried out in male and female mice.
To accurately isolate the early DCT (DCT1) segments, microdissection was performed in a Pvalb-cre tdTomato transgenic mouse model. Transcript profiles in male and female DCT1 segments revealed comprehensive sex differences in the molecular features of the early DCT segments. Our data provide a high-resolution DCT1 (early DCT) transcriptome and serve as a reference resource for DCT research.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269410 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE269410 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1121399 ncbi.nlm.nih.gov/bioproject/PRJNA1121399 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Bioinformatics and computational biology 70% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE269410 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3102 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |