Omics · study · 2026
Effect of treatment of NP1192 on gene expression of SiHa cervical cancer cells.
Listed in NCBI GEO
Epigenetics has emerged as the most prominent oncogenic driver under investigation in recent years.
Description
NAT10, a highly conserved N-acetyltransferase 10, contributes to the development of multiple malignancies through post-transcriptionally acetylating cytidine’s fourth carbon to the form ac4C, necessitating development of targeted therapeutics. Here we report the identification of NP1192 as the first highly potent and selective PROTAC degrader targeting NAT10, which degrades and inhibits ac4C modification.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE243nnn/GSE243233 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE243233 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1017450 ncbi.nlm.nih.gov/bioproject/PRJNA1017450 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE243233 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |