Omics · study · 2026
Single-neuron sequencing of PBN-projecting Sp5C neurons in CION or Sham mice
Listed in NCBI GEO
Parabrachial (PBN)-projecting the caudal part of spinal trigeminal nucleus (Sp5C) neurons are essential for trigeminal neuralgia-induced pain hypersensitivity, but the molecular identities of PBN-projecting Sp5C neurons remain unclear.
Description
We have employed single-neuron sequencing by Smart-seq3 to study PBN-projecting Sp5C neurons in chronic constriction injury of the infraorbital nerve(CION）model or Sham mice. This study suggest that the Tac1 gene serve as a specific marker for PBN-projecting Sp5C neurons and demonstrate transcriptional reprogramming induced by CION in PBN-projecting Sp5C Tac1 neurons.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE322nnn/GSE322600 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE322600 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1430692 ncbi.nlm.nih.gov/bioproject/PRJNA1430692 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Sequencing 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE322600 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |