Omics · study · 2026
Brain endothelial cells with inflammatory signature in CCM disease in hypoxia and normoxia conditions
Listed in NCBI GEO
The CCM endothelium is hypersensitive to angiogenesis and can induce a hypoxic program associated with changes in angiogenesis, inflammation, and endothelial-cell metabolism under normoxic conditions.
Description
It has been suggested that environmental, genetic, or biological factors act as disease modifiers. However, the underlying mechanisms are not entirely understood.
To assess whether mild hypoxia accelerates CCM, we employed a CCM mouse model (Pdcd10BECKO;Aldh1l1-EGFP/Rpl10a). Brain endothelial cells (BECs) were isolated from Slco1c1-iCreERT2;Pdcd10fl/fl;Aldh1l1-EGFP/Rpl10a mice to as previously described. BECs mRNAs were from isolated microvesels from cerebral tissue of mice age P50 exposed to hypoxia or normoxia conditions.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE261nnn/GSE261224 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE261224 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1085778 ncbi.nlm.nih.gov/bioproject/PRJNA1085778 ↗
project · from NCBI GEO
- PubMed 38660801 pubmed.ncbi.nlm.nih.gov/38660801 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE261224 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |