Omics · study · 2026
A Critical Role for the Mitochondrial Pyruvate Carrier in Hepatic Stellate Cell Activation
Listed in NCBI GEO
Activated hepatic stellate cells are the primary mediators of the development of fibrosis in a variety of chronic liver diseases.
Description
Genetic inhibition of the mitochondrial pyruvate carrier, which catalyzes an important step in intermediary metabolism, suppresses hepatic stellate cell activation. These studies identify new metabolic mechanisms that regulate stellate cell function and highlight the potential of targeting mitochondrial metabolism for treating fibrotic liver disease.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345305 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345305 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1519932 ncbi.nlm.nih.gov/bioproject/PRJNA1519932 ↗
project · from NCBI GEO
- PubMed 40239806 pubmed.ncbi.nlm.nih.gov/40239806 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE345305 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |