Excel · study · 2026
LTBP4 Deficiency Inhibits NLRP3 Inflammasome Activation in Cardiomyocytes and Attenuates Heart Failure
Listed in NCBI GEO
The complex mechanisms underlying the roles of inflammation in heart failure remain incompletely understood.
Description
In this study, we elucidate the significant role of LTBP4 in heart failure. LTBP4 was capable of promoting the interaction between NLRP3 and NEK7 and activating the NLRP3 inflammasome signaling pathway.
The 1574-1624 amino acids of LTBP4 were essential for this process. Inhibition of LTBP4 improves heart function post-TAC, highlighting its potential as a new therapeutic target for heart failure.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE287nnn/GSE287829 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE287829 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1214778 ncbi.nlm.nih.gov/bioproject/PRJNA1214778 ↗
project · from NCBI GEO
- PubMed 42140931 pubmed.ncbi.nlm.nih.gov/42140931 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Heart 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE287829 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |