Omics · study · 2026
Positively charged Ce-doped polypyrrole nanoparticles ameliorate acute kidney injury by endo-exogenous regulation of oxidative stress
Listed in NCBI GEO
Acute kidney injury (AKI) remains a critical clinical challenge with rapid renal function decline and limited therapeutic options.
Description
Mitochondrial reactive oxygen species (ROS)-induced oxidative stress drives AKI progression. This study develops a novel nanomedicine strategy utilizing cerium-doped polypyrrole (CePPy) nanoparticles to target ischemia-reperfusion injury-induced AKI.
Synthesized via a green, one-step method, CePPy shows broad-spectrum antioxidant properties, and its positive surface charge enhances renal uptake and therapeutic efficacy compared to negatively charged counterparts. We demonstrate that positively charged CePPy (designated (+)CePPy), preferentially accumulates in the mitochondria of injured proximal tubular epithelial cells (PTECs) through transcytosis from peritubular capillaries.
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The (+)CePPy exhibits strong ROS scavenging capabilities as an exogenous antioxidant, and bolsters endogenous mitochondrial defenses via Mpv17l-dependent mechanisms, demonstrating significant protective effects in AKI models and preventing progression to chronic kidney disease. Furthermore, PTECs eliminate nearly 90% of CePPy within 14 days, indicating exceptional clearance efficiency. These findings highlight the potential of (+)CePPy as a promising therapeutic strategy for AKI, with significant implications for clinical translation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313051 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313051 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1378193 ncbi.nlm.nih.gov/bioproject/PRJNA1378193 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313051 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |