Omics · study · 2026
Integrative transcriptomic analysis reveals Cytip as a novel pro-inflammatory factor which interacting with Lrrfip2 in microglia following
Listed in NCBI GEO
In this study, we sought to elucidate the transcriptional landscape of microglia during the acute phase of cerebral I/R injury.
Description
By integrating transcriptomic data from an in vivo mouse model of middle cerebral artery occlusion/reperfusion (MCAO/R), with in vitro bulk RNA sequencing of Bv2 microglia subjected to oxygen-glucose deprivation/reperfusion (OGD/R), we identified Cytip (Cytohesin Interacting Protein) as significantly upregulated.
Our results demonstrated that CYTIP expression peaked 24 h post-reperfusion and its knockdown markedly attenuated neuroinflammation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326830 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326830 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1447425 ncbi.nlm.nih.gov/bioproject/PRJNA1447425 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326830 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |