Omics · study · 2026
Cold-inducible RNA-binding protein promotes lung fibroblast activation via TLR2/4-dependent IL-6 signaling: implications in pulmonary fibrosis
Listed in NCBI GEO
This study investigates the role of Cold-inducible RNA-binding protein (CIRBP) in the pathogenesis of pulmonary fibrosis.
Description
Using RNA-seq, we analyzed gene expression changes in primary mouse lung fibroblasts stimulated with recombinant CIRBP or PBS control. CIRBP significantly upregulated cytokine-related gene expression, including IL-6, and promoted collagen production and fibroblast proliferation via TLR2/4 pathways.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294583 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294583 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1250537 ncbi.nlm.nih.gov/bioproject/PRJNA1250537 ↗
project · from NCBI GEO
- PubMed 41667819 pubmed.ncbi.nlm.nih.gov/41667819 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE294583 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |