Omics · study · 2026
Identification of IPF Specific Genes Expressed by Lung Tissue - Derived Fibroblasts Using Next Generation Sequencing
Listed in NCBI GEO
This study presents transcriptomic profiling of primary lung fibroblasts derived from patients with idiopathic pulmonary fibrosis (IPF) and histologically normal controls.
Description
Total RNA sequencing was performed to identify differentially expressed genes associated with fibroblast activation in IPF. A total of 43 samples (33 IPF and 10 controls) were analyzed.
The results revealed robust gene expression changes in IPF fibroblasts, with significant enrichment in extracellular matrix organization and collagen-related pathways. This dataset provides a valuable resource for understanding the molecular landscape of IPF fibroblasts and may facilitate the identification of novel biomarkers and therapeutic targets.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301181 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301181 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1284232 ncbi.nlm.nih.gov/bioproject/PRJNA1284232 ↗
project · from NCBI GEO
- PubMed 41891414 pubmed.ncbi.nlm.nih.gov/41891414 ↗
publication · from NCBI GEO
- PubMed 42329017 pubmed.ncbi.nlm.nih.gov/42329017 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Genetics 71% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE301181 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |