Multi-omic analysis reveals brain-blood concordance and persistent neuroimmune reprogramming with stress and toxicant exposure in a mouse model of Gulf War Illness [RRBS]

Adult male C57BL/6J mice were exposed to corticosterone (CORT) and diisopropyl fluorophosphate (DFP), followed by repeated intermittent CORT and a later immune challenge with lipopolysaccharide (LPS) or saline. Reduced representation bisulfite sequencing (RRBS) was used to profile DNA methylation in whole blood, hippocampus, and frontal cortex collected 6 h, 12 h, and 24 h after challenge.