Omics · study · 2026
Plasma Extracellular Vesicle Modulate Immune Cell Transcriptional Responses Following Acute Myocardial Infarction
Listed in NCBI GEO
Plasma extracellular vesicles (EVs) increase during acute myocardial infarction (MI), correlate with myocardial injury, and mobilise immune cells from the spleen to the circulation.
Description
These cells are transcriptionally activated even before tissue recruitment, yet the mechanisms driving this priming are unclear. We show that plasma EVs isolated at hospital presentation with MI are enriched in miRNA‑320b.
Endothelial cells upregulate miRNA‑320b in EVs following inflammatory stimulation. Target gene pathway analysis revealed enrichment in adhesion and cytokine signalling. Endothelial EVs promoted monocyte adhesion and induced IL6 and TNF mRNA expression in macrophages while dampening cytokine secretion.
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RNA-sequencing of MI patient neutrophils and monocytes confirmed significant enrichment of miRNA‑320b targets. Peripheral blood mononuclear cells treated with MI EVs showed similar gene regulation. These findings suggest that EV‑mediated transfer of miRNA‑320b primes immune cells for adhesion and cytokine signalling.
Understanding this axis may enable therapeutic immunomodulation of immune cells to improve repair following MI.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313527 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313527 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1380110 ncbi.nlm.nih.gov/bioproject/PRJNA1380110 ↗
project · from NCBI GEO
- PubMed 41852720 pubmed.ncbi.nlm.nih.gov/41852720 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Myocardial infarction 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313527 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:myocardial-infarction | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |