Omics · study · 2026
Effect of levofloxacin on apoptosis pathways in SW48 colorectal cancer cells
Listed in NCBI GEO
We profiled transcriptomic changes in SW48 cells after 5-day 100μM levofloxacin treatment.
Description
Levofloxacin induces DNA damage and moderate p53 activation biased toward DNA repair over pro-apoptotic programs, while remodeling mitochondrial metabolism via enhanced OXPHOS and ROS accumulation. Though levofloxacin alone does not trigger robust apoptosis, it primes cells for apoptotic sensitivity via metabolic stress and redox imbalance, defining a novel anti-tumor mechanism of this clinical antimicrobial.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341447 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341447 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1502775 ncbi.nlm.nih.gov/bioproject/PRJNA1502775 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE341447 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |