Omics · study · 2026
Evaluation of the antiatrophic effect Lachnospira eligens supernatant on myotubes
Listed in NCBI GEO
Lachnospira eligens (LE) was identified as a novel probiotic candidate in the multi-centric prospective observational clinical study MicroAML (ClinicalTrials.gov Identifier NCT03881826).
Description
LE abundance was reduced in acute myeloid leukemia (AML) patients as compared to healthy individuals, and correlated with muscle strength. The antiatrophic effect of LE supernatant was assessed and confirmed in vitro.
RNAseq analysis was performed in a pool of two independent experiments in which murine C2C12 myotubes were incubated or not with LE H260 supernatant filtered at 1 kDa, in the presence or not of the atrophying agent dexamethasone, for 48 hours.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328252 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328252 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1454441 ncbi.nlm.nih.gov/bioproject/PRJNA1454441 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328252 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |