Imaging · study · 2026
The HFE H63D variant in pancreatic cancer promotes epithelial-to-mesenchymal transition at the expense of cell cycle
Listed in NCBI GEO
This study examines the biological and clinical relevance of the HFE H63D variant in pancreatic ductal adenocarcinoma (PDAC), a highly aggressive cancer with limited biomarkers.
Description
We analyzed its prevalence in PDAC cohorts and explored associations with tumor characteristics and patient outcomes. Functional studies in human cell lines and genetically engineered mouse models (KCh67d vs. KCwt) revealed effects on cell cycle arrest and epithelial-to-mesenchymal transition (EMT), suggesting a role in tumor progression.
Spatial transcriptomics was used to dissect the tumor microenvironment, supporting the potential of H63D as a prognostic biomarker and therapeutic stratification factor.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297144 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297144 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1262885 ncbi.nlm.nih.gov/bioproject/PRJNA1262885 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE297144 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |